Keiser lab
Investigating sex-specific mechanisms of memory and
cognitive decline in aging and Alzheimer's disease
About us
Our lab is dedicated to unraveling molecular mechanisms underlying memory processing, with a keen focus on sex differences in the adult, aging, and Alzheimer’s Disease (AD) brain. By investigating the role of ACVR1C, a pivotal receptor in memory formation, we aim to elucidate how its regulation impacts cognitive decline and identify potential therapeutic targets. Our research integrates behavioral insights and advanced molecular techniques to foster a deeper understanding of memory impairments and inform treatment strategies, especially for conditions that disproportionately affect women. Together, we seek to contribute transformative knowledge that could ultimately reshape interventions for memory-related disorders.
Projects
Investigating ACVR1C: Epigenetic Regulation and Memory Impairments
Our study shows that ACVR1C declines with age and Alzheimer's Disease (AD), acting as an epigenetic regulator that suppresses memory-related genes, contributing to memory deficits.
Understanding Sex Differences in Memory Processing Mechanisms
Women are more affected by cognitive disorders like Alzheimer’s and PTSD. Investigating sex-specific mechanisms, like ACVR1C regulation, could lead to personalized memory loss treatments.
Join us
We are currently seeking a dedicated Graduate Researcher to join our team for Fall 2026! Please see the form below and inquire at: ashley.keiser@asu.edu.
Recent Papers
LaTour S, Shaikh H, Beardwood JH, Augustynski AS, Wood MA, Keiser AA (2024) The weekend warrior effect: Consistent intermittent exercise induces persistent cognitive benefits. Neurobiology of Learning and Memory. Read More
Keiser AA, Dong T, Kramár EA, Butler CW, Chen S, Matheos DP, Beardwood J, Augustynski AS, Al-Shammari A, Alaghband Y, Alizo Vera V, Berchtold NC, Shanur S, Baldi P, Cotman CW, Wood MA (2024) Specific exercise patterns generate an epigenetic molecular memory window that drives long-term memory formation and identifies ACVR1C as a bidirectional regulator of memory. Nature Communications. Read More
Perez-Sisques L, Bhatt S, Matuleviciute R, Gileadi T, Kramár EA, Graham A, Garcia F, Keiser AA, Matheos DP, Cain J, Pittman A, Andreae L, Fernandes C, Wood MA, Giese K, Basson M (2024) The intellectual disability risk gene kdm5b regulates long term memory consolidation in the hippocampus. Journal of Neuroscience. Read More